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Research Snapshot Theater: Cardiovascular, Adult VIII

LV Strain Predicts Long-Term Outcomes in Sepsis: A Retrospective Multicenter Study

Monday, March 23, 2026
2:30 PM - 3:30 PM Central Time
Location: Connections Central - RST 02

  • Ivan Huespe, MD

    Buenos Aires, Argentina

    Disclosure(s): No relevant financial relationship(s) to disclose.

  • FS

    Fernando Sosa, MD

    Physician
    Hospital Italiano de Buenos Aires

    Disclosure information not submitted.

  • Anek Jena, n/a

    Illinois

    Disclosure(s): No relevant financial relationship(s) to disclose.

  • AP

    Aayushi Pareek, MD

    Research Trainee
    Mayo Clinic, Jacksonville, Florida

    Disclosure information not submitted.

  • FS

    Faiz Saleem, MD

    Research Fellow
    Mayo Clinic, Jacksonville, Florida

    Disclosure information not submitted.

  • SB

    Said Bateh, B.S

    Research Trainee
    Mayo Clinic, Jacksonville, Florida

    Disclosure information not submitted.

  • JS

    Jose Soto Soto, MD

    Pulmonologist
    Mayo Clinic, Jacksonville, Florida

    Disclosure information not submitted.

  • JD

    Jose Delgado, MD

    Research Fellow
    Mayo Clinic, Jacksonville, Florida

    Disclosure information not submitted.

  • Saurabh Sujanyal, MBBS

    Disclosure(s): No relevant financial relationship(s) to disclose.

  • Rosa Corro, MD (she/her/hers)

    Mayo Clinic Hospital in Florida, Florida

    Disclosure(s): No relevant financial relationship(s) to disclose.

  • Aryan Pathak, BS (he/him/his)

    Florida

    Disclosure(s): No relevant financial relationship(s) to disclose.

  • Vrutti Patel, BS (she/her/hers)

    Florida

    Disclosure(s): No relevant financial relationship(s) to disclose.

  • LA

    Lucia Andrade, MD

    Physician
    Hospital Alemán, Buenos Aires, Argentina

    Disclosure information not submitted.

  • BO

    Barbara Oribe, MD

    Physician
    Hospital Alemán, Buenos Aires, Argentina

    Disclosure information not submitted.

  • FD

    Federico Daldoss, MD

    Physician
    Hospital Alemán, Buenos Aires, Argentina

    Disclosure information not submitted.

  • AS

    Anna Shapiro, MD

    Consultant, Anesthesiology and Critical Care
    Mayo Clinic Florida

    Disclosure information not submitted.

  • NP

    Neal Patel, MD

    Pulmonologist
    Mayo Clinic, Jacksonville, Florida

    Disclosure information not submitted.

  • PG

    Pramod Guru, MD

    Consultant, Critical Care Medicine
    Mayo Clinic Hospital in Florida

    Disclosure information not submitted.

  • PM

    Pablo Moreno Franco, MD

    Chair, Critical Care Medicine
    Mayo Foundation for Medical Education

    Disclosure information not submitted.

  • Devang Sanghavi, MD, MHA

    Mayo Clinic Hospital in Florida, Florida

    Disclosure information not submitted.

Introduction: Sepsis survivors face an increased risk of long-term cardiovascular disease, yet traditional assessments often fail to identify those at risk. We investigated the prognostic utility of Left Ventricular Global Longitudinal Strain (LV GLS) in patients with sepsis and preserved Left ventricle Ejection fraction (LVEF), aiming to evaluate subclinical cardiac risk undetectable by the standard measure


Methods: This retrospective study included 439 patients with sepsis or septic shock hospitalized between 2018–2022 at five Mayo Clinic sites (USA) and Hospital Alemán (Argentina). Echocardiographic strain imaging within 7 days of admission classified LV global longitudinal strain (GLS) as normal (–23% to –14%), hypercontractile (≤ –23%), or impaired (> –14%): 328 (74.7%) had normal, 31 (7.1%) low, and 80 (18.2%) high GLS. Outcomes were Major Adverse Cardiovascular Events (MACE: CV death, stroke, MI) and non-cardiovascular death. Fine–Gray and Cox models assessed associations, adjusting for demographics, comorbidities, SOFA score, lactate, mechanical ventilation, inotropes, vasopressors, and acute kidney injury.


Results: Of 439 patients, 178 (40.5%) were female, with a median age of 62.9 years (overall) and 57.8 years (females). Among patients with preserved LVEF, impaired strain (> –14%) was significantly associated with MACE (adjusted sHR 1.58, 95% CI 1.10–2.20; p < 0.01), while LVEF itself was not (sHR 1.00, p = 0.99). MACE occurred over a median follow-up of 2.1 years (IQR 0.66–3.2), with 77 patients experiencing MACE during 595 patient-years of follow-up. Non-CV deaths occurred with a median time to death of 0.1 years (IQR 0.02–0.45). Hypercontractile strain (≤ –23%) was not associated with MACE but was independently predictive of non-CV death (adjusted sHR 1.93, p < 0.01), suggesting that elevated systolic function during sepsis could suggest persistent impaired cardiac function rather than cardiac recovery.


Conclusions: This study reflects an area that needs to be studied for post-sepsis cardiac care; many patients at risk for long-term cardiovascular events may appear “normal” by LVEF but might have clinically significant systolic dysfunction detectable only by strain imaging. LV GLS could detect a high-risk subgroup within the preserved LVEF population and become a more reliable prognostic tool.