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Pediatrics
Concurrent

Clot if You Don't, Bleed if You Do: Pediatric Venous Thromboembolism Risk and Prevention

Tuesday, March 24, 2026
2:30 PM - 3:30 PM Central Time
Location: W185

Epidemiologic data reveal an increase in the incidence and/or recognition of pediatric venous thromboembolism by 130% to 200% during the past two decades. While the American College of Physicians recommends thromboprophylaxis for hospitalized adults without contraindication, the lack of phase 3 trials of pediatric pharmacologic thromboprophylaxis precludes the creation of universal thromboprophylaxis recommendations for hospitalized children, many of whom are at increased risk of major bleeding. Speakers, who are experts in pediatric thrombosis and hemostasis, will discuss at-risk, prothrombotic pediatric subpopulations and those at elevated risk of bleeding (including from anticoagulant exposure) to spur active dialogue, collaboration, and networking opportunities around a common conundrum routinely faced by clinicians.

Learning Objectives:

  • Review the evidence for risk factors associated with hospital-acquired venous thromboembolism (VTE) in critically ill children
  • Assess the evidence for risk factors associated with clinically relevant bleeding in critically ill children
  • Evaluate current evidence for the efficacy and safety of pediatric thromboprophylaxis including mechanical and pharmacologic strategies
  • Appraise the results of phase 2 pediatric thromboprophylaxis randomized controlled trials and ongoing phase 3 clinical trials in hospital-acquired VTE prevention in critically ill children
  • Explain approaches to common clinical case scenarios, balancing the risk of clinically relevant bleeding and hospital-acquired VTE

Presentations:

  • 2:35 PM - 2:50 PM Central Time
    Clotting Risk in Pediatric Critical Care

    Marisol A. Betensky, MD

  • 2:50 PM - 3:05 PM Central Time
    Bleeding Risk in Pediatric Critical Care

    Hilary Whitworth, MD, , MSCE (she/her/hers) – The Children's Hospital of Philadelphia

  • 3:05 PM - 3:20 PM Central Time
    Current Clinical Trials for Managing and Preventing Thrombosis in the PICU and Thromboprophylaxis in Pediatric Critical Illness

    Anthony A. Sochet, MD, (he/him/his) – Johns Hopkins University