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Final Program


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Thought Leader Session
Thought Leader Session
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Aging Adult Track
Aging Adult Track
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Additional Registration Fee

Naoki Hayase, n/a (he/him/his)

National Institutes of Health, Maryland

I am Naoki Hayase, M.D., Ph.D., a visiting fellow at the National Institute of Health (NIH). My research focuses on multiple organ dysfunction syndrome (MODS) and sepsis. I am particularly interested in elucidating the mechanisms underlying MODS in sepsis, developing novel therapeutic strategies, and establishing point-of-care testing methods to identify patient populations most likely to benefit from these interventions. I am a board-certified emergency physician and intensivist with over ten years of clinical experience in Japan. After earning my M.D. from the University of Tokyo, I completed my Ph.D. at its Graduate School of Medicine. Drawing on my clinical background, I have investigated sepsis and ischemia-reperfusion (IR)-induced multiple organ dysfunction using both clinical and basic science approaches. Through this work, I gained extensive experience in clinical research (study design, patient recruitment, data management, and statistical analysis) and training in laboratory techniques such as mouse surgery (superior mesenteric artery ischemia-reperfusion and bilateral renal ischemia-reperfusion models). During my postdoctoral training in NIH, I have mastered several advanced surgical techniques in mice, including cecal ligation and puncture (CLP), jugular vein catheterization, and osmotic minipump implantation. Using these methods, I am developing a therapeutic strategy for CLP-induced sepsis based on time-lagged continuous infusion of anticoagulants. Additionally, I have gained experience in primary culture of mouse proximal tubular cells and bulk RNA sequencing data analysis. I am investigating how mitochondrial DNA induces oxidative stress in tubular cells and how the mitochondrial uncoupler BAM15 mitigates this process. I have also learned methods to extract mitochondrial DNA from blood and urine samples in various species, quantify it using real-time PCR, and evaluate reactive oxygen species by a confocal microscope. I am applying these techniques to study the preventive effects of dietary supplements on cardiac surgery-associated acute kidney injury in collaboration with George Washington University.

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